Kyle L Hoehn Selected Research

Ceramides

1/2018	A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.
3/2007	Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance.
8/2004	Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

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Kyle L Hoehn Research Topics

Disease

19	Obesity 01/2024 - 03/2007
17	Neoplasms (Cancer) 03/2023 - 06/2012
16	Insulin Resistance 08/2022 - 08/2004
8	Endometrial Neoplasms (Endometrial Cancer) 03/2023 - 06/2012
5	Liver Neoplasms (Liver Cancer) 01/2024 - 07/2014
5	Weight Loss (Weight Reduction) 01/2024 - 07/2009
5	Fatty Liver 01/2024 - 07/2014
5	Body Weight (Weight, Body) 01/2024 - 08/2015
4	Non-alcoholic Fatty Liver Disease 01/2023 - 01/2020
4	Glucose Intolerance 01/2018 - 03/2015
3	Metabolic Diseases (Metabolic Disease) 01/2023 - 01/2016
3	Hyperglycemia 01/2023 - 02/2016
3	Inflammation (Inflammations) 11/2022 - 05/2008
3	Type 2 Diabetes Mellitus (MODY) 10/2021 - 06/2017
3	Breast Neoplasms (Breast Cancer) 10/2021 - 10/2019
3	Carcinogenesis 09/2018 - 02/2016
3	Hyperinsulinism (Hyperinsulinemia) 01/2018 - 05/2008
2	Hypertriglyceridemia 01/2024 - 01/2023
2	Neoplasm Metastasis (Metastasis) 04/2022 - 10/2021
2	Fibrosis (Cirrhosis) 12/2020 - 11/2020
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 12/2017 - 10/2015
2	Infections 01/2016 - 01/2015
1	Peritonitis 11/2022
1	Hepatocellular Carcinoma (Hepatoma) 04/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020
1	Necrosis 01/2020
1	Coenzyme Q10 Deficiency 01/2018
1	Melanoma (Melanoma, Malignant) 01/2018
1	Nevus (Nevi) 01/2018
1	Morbid Obesity 01/2018
1	Sarcopenia 01/2018

Drug/Important Bio-Agent (IBA)

14	Glucose (Dextrose)FDA LinkGeneric 01/2024 - 10/2009
12	Insulin (Novolin)FDA Link 01/2021 - 05/2008
11	LipidsIBA 01/2020 - 06/2007
7	Proteins (Proteins, Gene)FDA Link 01/2018 - 03/2004
6	EnzymesIBA 01/2019 - 03/2007
5	Triglycerides (Triacylglycerol)IBA 12/2020 - 03/2016
4	Acetyl-CoA CarboxylaseIBA 11/2022 - 06/2012
4	Biomarkers (Surrogate Marker)IBA 01/2018 - 10/2016
4	Fatty Acids (Saturated Fatty Acids)IBA 01/2018 - 03/2007
3	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 11/2021 - 03/2015
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 04/2014
3	Dietary SugarsIBA 09/2018 - 03/2015
3	AntioxidantsIBA 01/2018 - 10/2009
3	CeramidesIBA 01/2018 - 08/2004
2	semaglutideIBA 01/2024 - 01/2024
2	Circular RNAIBA 03/2023 - 01/2018
2	mitochondrial uncoupler BAM15IBA 01/2023 - 01/2020
2	Interleukin-6 (Interleukin 6)IBA 11/2022 - 03/2015
2	Blood Glucose (Blood Sugar)IBA 08/2022 - 10/2021
2	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 08/2022 - 10/2014
2	PyrazinesIBA 10/2021 - 12/2020
2	Glutamine (L-Glutamine)FDA Link 01/2020 - 10/2019
2	SphingolipidsIBA 10/2019 - 03/2007
2	Superoxides (Superoxide)IBA 01/2018 - 10/2009
2	RNA (Ribonucleic Acid)IBA 01/2018 - 12/2017
2	Long Noncoding RNAIBA 12/2017 - 10/2016
2	SugarsIBA 02/2016 - 03/2015
2	CarcinogensIBA 02/2016 - 03/2015
2	Dietary Fats (Dietary Fat)IBA 02/2016 - 03/2015
2	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 10/2015 - 03/2004
2	AdiponectinIBA 03/2015 - 01/2010
1	FructoseIBA 01/2024
1	Rosiglitazone (Avandia)FDA Link 01/2024
1	CytokinesIBA 11/2022
1	16S Ribosomal RNAIBA 04/2022
1	GlobosidesIBA 04/2022
1	GangliosidesIBA 04/2022
1	GlycosphingolipidsIBA 04/2022
1	Sulfoglycosphingolipids (Sulfatides)IBA 04/2022
1	ceramide glucosyltransferaseIBA 11/2021
1	Adenosine Triphosphate (ATP)IBA 10/2021
1	Antineoplastic Agents (Antineoplastics)IBA 10/2021
1	Phenobarbital (Luminal)FDA Link 10/2021
1	DiaminesIBA 12/2020
1	Alanine Transaminase (SGPT)IBA 11/2020
1	Vitamin K 3 (Menadione)FDA Link 01/2020
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2020
1	NaphthoquinonesIBA 01/2020
1	1,4-naphthoquinoneIBA 01/2020
1	Glutathione Disulfide (GSSG)FDA LinkGeneric 01/2020
1	tanespimycin (17AAG)IBA 01/2020
1	QuinonesIBA 01/2020
1	Phosphopyruvate Hydratase (Enolase)IBA 01/2019
1	VemurafenibIBA 01/2018
1	Deoxyglucose (2 Deoxy D glucose)IBA 01/2018
1	Glutathione (Reduced Glutathione)IBA 01/2018
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2018
1	trametinibIBA 01/2018
1	Mevalonic Acid (Mevalonate)IBA 01/2018
1	dihydroceramide desaturaseIBA 01/2018
1	ThioredoxinsIBA 01/2018
1	Oxidants (Oxidizing Agents)IBA 01/2018
1	Mitogen-Activated Protein KinasesIBA 01/2018
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2018

Therapy/Procedure

9	Therapeutics 01/2023 - 03/2007
3	Drug Therapy (Chemotherapy) 01/2023 - 01/2020
1	Aftercare (After-Treatment) 10/2021
1	Glycemic Control 01/2020
1	Ketogenic Diet 09/2018